Mengjuei - Blog

日誌 :: Professor Chen-Chung Yang (1927-2005)

My uncle professor Chen-Chung Yang, an academician professor of Academia Sinica passed away on January 25th, at the age of seventy eight. He was well-respected in the field of protein chemistry and the study of snake venom. He was also a pioneer of biological research in Taiwan. He has received numerous important appointments, awards and honors, we can never forget his scientific achievements and great contribution to the education in Taiwan.
The funeral will be held on February 3rd in HsinChu, Taiwan.

Also check Who's Who in the ROC

This is his recent publication list:
• Chang, LS; Wu, PF; Liou, JC; et al. Chemical modification of arginine residues of Notechis scutatus scutatus notexin. TOXICON, 44 (5): 491-497 OCT 2004
• Liou, JC; Cheng, YC; Kang, KH; et al. Both A chain and B chain of beta-bungarotoxin are functionally involved in the facilitation of spontaneous transmitter release in Xenopus nerve-muscle cultures. TOXICON, 43 (3): 341-346 MAR 1 2004
• Chang, LS; Chung, CL; Liou, JC; et al. Novel neurotoxins from Taiwan banded krait (Bungarus multicinctus) venom: purification, characterization and gene organization. TOXICON, 42 (3): 323-330 SEP 2003
• Chang, LS; Chung, C; Wu, BN; et al. Characterization and gene organization of Taiwan banded krait (Bungarus multicinctus) gamma-bungarotoxin. JOURNAL OF PROTEIN CHEMISTRY, 21 (4): 223-229 MAY 2002
• Chang, LS; Lin, SR; Yang, CC. Glutaraldehyde cross-linking alters the environment around Trp(29) of cobrotoxin and the pathway for regaining its fine structure during refolding. JOURNAL OF PEPTIDE RESEARCH, 58 (2): 173-179 AUG 2001
• Chang, LS; Lin, SR; Yang, CC. Refolding of Taiwan cobra neurotoxin: Intramolecular cross-link affects its refolding reaction. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 387 (2): 289-296 MAR 15 2001
• Chang, LS; Chen, KC; Wu, BN; et al. Expression and mutagenesis studies of cobrotoxin from Taiwan cobra. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 263 (3): 652-656 OCT 5 1999
• Yang, CC. Cobrotoxin: Structure and function. JOURNAL OF NATURAL TOXINS, 8 (2): 221-233 JUN 1999
• Yang, CC; Chang, LS. Biochemistry and molecular biology of snake neurotoxin. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 46 (3): 319-332 JUN 1999
• Yang, CC; Chan, HL. Preparation and characterization of beta(1)-bungarotoxin bispecific monoclonal antibody. BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 47 (6): 1039-1048 JUN 1999
• Yang, CC; Chan, HL. Immunochemical study on beta(1)-bungarotoxin using polyclonal and monoclonal antibodies. TOXICON, 37 (5): 729-742 MAY 1999
• Chang, LS; Lin, SR; Chang, CC; et al. Disulfide isomerization within the C-terminus of cobrotoxin decelerates by thiol compounds and trinitrophenylation, but accelerates by modification of carboxyl groups. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 358 (1): 164-170 OCT 1 1998
• Chu, RC; Yang, CC. Cloning and sequence analysis of novel cardiotoxins/CLBP from venom glands of Naja naja atra. BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 44 (5): 1021-1030 APR 1998
• Yang, CC; Chan, HL. Neutralizing epitope mapping of six beta(1)-bungarotoxin monoclonal antibodies and its application in beta(1)-bungarotoxin peptide vaccine design. BIOCHEMICAL JOURNAL, 330: 497-503 Part 1 FEB 15 1998
• YANG, CC. STRUCTURE AND FUNCTION OF COBRA NEUROTOXIN. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 209: 39-AGFD Part 1 APR 2 1995
• CHIOU, SH; HUNG, CC; HUANG, HC; et al. SEQUENCE COMPARISON AND COMPUTER MODELING OF CARDIOTOXINS AND COBROTOXIN ISOLATED FROM TAIWAN COBRA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 206 (1): 22-32 JAN 5 1995
• YANG, CC. STRUCTURE AND FUNCTION OF COBROTOXIN. JOURNAL OF TOXICOLOGY-TOXIN REVIEWS, 13 (3): 275-290 1994
• YU, C; BHASKARAN, R; YANG, CC. STRUCTURES IN SOLUTION OF TOXINS FROM TAIWAN COBRA VENOM, NAJA-NAJA-ATRA, DERIVED FROM NMR-SPECTRA. JOURNAL OF TOXICOLOGY-TOXIN REVIEWS, 13 (3): 291-315 1994
• BHASKARAN, R; YU, C; YANG, CC. SOLUTION STRUCTURES AND FUNCTIONAL IMPLICATIONS OF THE TOXINS FROM TAIWAN COBRA VENOM, NAJA-NAJA-ATRA. JOURNAL OF PROTEIN CHEMISTRY, 13 (5): 503-504 JUL 1994
• YANG, CC. STRUCTURE-FUNCTION RELATIONSHIP OF PHOSPHOLIPASE A(2) FROM SNAKE-VENOMS. JOURNAL OF TOXICOLOGY-TOXIN REVIEWS, 13 (2): 125-177 1994
• CHANG, LS; LIN, SR; CHANG, CC; et al. THE ESSENTIALITY OF B-CHAIN IN STABILIZING THE STRUCTURE OF THE A CHAIN IN BETA(1)-BUNGAROTOXIN FROM BUNGARUS-MULTICINCTUS VENOM. JOURNAL OF PROTEIN CHEMISTRY, 13 (2): 233-236 FEB 1994
• CHANG, LS; YANG, CC. STRUCTURAL DETERMINANTS OF THE INTRINSIC FLUORESCENCE EMISSION IN NOTEXIN AND PHOSPHOLIPASE-A(2) ENZYMES. JOURNAL OF PROTEIN CHEMISTRY, 12 (5): 579-583 OCT 1993
• CHANG, LS; YANG, CC. SEPARATION AND CHARACTERIZATION OF THE A-CHAIN AND B-CHAIN IN BETA-1-BUNGAROTOXIN FROM BUNGARUS-MULTICINCTUS (TAIWAN BANDED KRAIT) VENOM. JOURNAL OF PROTEIN CHEMISTRY, 12 (4): 469-475 AUG 1993
• YU, C; BHASKARAN, R; CHUANG, LC; et al. SOLUTION CONFORMATION OF COBROTOXIN - A NUCLEAR-MAGNETIC-RESONANCE AND HYBRID DISTANCE GEOMETRY DYNAMIC SIMULATED ANNEALING STUDY. BIOCHEMISTRY, 32 (9): 2131-2136 MAR 9 1993
• YANG, CC. CHEMISTRY OF SNAKE NEUROTOXINS AND FUTURE PERSPECTIVES. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 39 (6): 731-740 DEC 1992
• YANG, CC; CHANG, LS; ONG, PL; et al. IMMUNOCHEMICAL PROPERTIES OF NAJA-NAJA-ATRA (TAIWAN COBRA) PHOSPHOLIPASE-A2 USING POLYCLONAL AND MONOCLONAL-ANTIBODIES. TOXICON, 30 (2): 151-159 FEB 1992
• YANG, CC; CHANG, LS. DISSOCIATION OF LETHAL TOXICITY AND ENZYMATIC-ACTIVITY OF NOTEXIN FROM NOTECHIS-SCUTATUS-SCUTATUS (AUSTRALIAN-TIGER-SNAKE) VENOM BY MODIFICATION OF TYROSINE RESIDUES. BIOCHEMICAL JOURNAL, 280: 739-744 Part 3 DEC 15 1991
• YANG, CC; CHANG, LS; WU, FS. VENOM CONSTITUENTS OF NOTECHIS-SCUTATUS-SCUTATUS (AUSTRALIAN TIGER SNAKE) FROM DIFFERING GEOGRAPHIC REGIONS. TOXICON, 29 (11): 1337-1344 1991
• CHANG, LS; TUNG, TH; ONG, PL; et al. A CONVENIENT METHOD TO DIFFERENTIATE THE MONOCLONAL-ANTIBODIES WITH DIFFERING IMMUNOCHEMICAL PROPERTIES. BIOCHEMISTRY INTERNATIONAL, 23 (6): 1063-1069 APR 1991
• YANG, CC; CHANG, LS. THE N-TERMINAL AMINO GROUP ESSENTIAL FOR THE BIOLOGICAL-ACTIVITY OF NOTEXIN FROM NOTECHIS-SCUTATUS-SCUTATUS VENOM. BIOCHIMICA ET BIOPHYSICA ACTA, 1040 (1): 35-42 AUG 1 1990
• YANG, CC; CHANG, LS. THE N-TERMINAL AMINO GROUP ESSENTIAL FOR THE BIOLOGICAL-ACTIVITY OF NOTEXIN FROM NOTECHIS-SCUTATUS-SCUTATUS VENOM. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 200: 67-AGFD Part 1 AUG 26 1990
• YANG, CC; CHANG, LS. STUDIES ON THE STATUS OF LYSINE RESIDUES IN PHOSPHOLIPASE-A2 FROM NAJA-NAJA-ATRA (TAIWAN COBRA) SNAKE-VENOM. BIOCHEMICAL JOURNAL, 262 (3): 855-860 SEP 15 1989
• ROSENBERG, P; GHASSEMI, A; CONDREA, E; et al. DO CHEMICAL MODIFICATIONS DISSOCIATE BETWEEN THE ENZYMATIC AND PHARMACOLOGICAL ACTIVITIES OF BETA-BUNGAROTOXIN AND NOTEXIN. TOXICON, 27 (2): 137-159 1989
• YANG, CC; CHANG, LS. ASSESSMENT OF THE ROLE OF TRYPTOPHAN RESIDUES IN PHOSPHOLIPASE-A2 BY FLUORESCENCE QUENCHING. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 11 (1): 13-16 FEB 1989
• CHANG, LS; YANG, CC. ROLE OF THE N-TERMINAL REGION OF THE A-CHAIN IN BETA-1-BUNGAROTOXIN FROM THE VENOM OF BUNGARUS-MULTICINCTUS (TAIWAN-BANDED KRAIT). JOURNAL OF PROTEIN CHEMISTRY, 7 (6): 713-727 DEC 1988
• YANG, CC; CHANG, LS. ROLE OF THE N-TERMINAL REGION IN PHOSPHOLIPASES-A2 FROM NAJA-NAJA-ATRA (TAIWAN COBRA) AND NAJA-NIGRICOLLIS (SPITTING COBRA) VENOMS. TOXICON, 26 (8): 721-731 1988
• WANG, CT; TSAI, WJ; CHANG, SM; et al. DIFFERENT SUSCEPTIBILITIES OF PLATELET PHOSPHOLIPIDS TO VARIOUS PHOSPHOLIPASES AND MODIFICATIONS INDUCED BY THROMBIN - POSSIBLE EVIDENCE OF REARRANGEMENT OF LIPID DOMAINS. BIOCHIMICA ET BIOPHYSICA ACTA, 899 (2): 205-212 MAY 29 1987
• YANG, CC; LEE, HJ. SELECTIVE MODIFICATION OF TYROSINE-68 IN BETA-1-BUNGAROTOXIN FROM THE VENOM OF BUNGARUS-MULTICINCTUS (TAIWAN BANDED KRAIT). JOURNAL OF PROTEIN CHEMISTRY, 5 (1): 15-28 FEB 1986
• SOONS, KR; CONDREA, E; YANG, CC; et al. EFFECTS OF MODIFICATION OF TYROSINES-3 AND 62 (63) ON ENZYMATIC AND TOXICOLOGICAL PROPERTIES OF PHOSPHOLIPASES A2 FROM NAJA-NIGRICOLLIS AND NAJA-NAJA-ATRA SNAKE-VENOMS. TOXICON, 24 (7): 679-693 1986
• RAPUANO, BE; YANG, CC; ROSENBERG, P. THE RELATIONSHIP BETWEEN HIGH-AFFINITY NONCATALYTIC BINDING OF SNAKE-VENOM PHOSPHOLIPASES-A2 TO BRAIN SYNAPTIC PLASMA-MEMBRANES AND THEIR CENTRAL LETHAL POTENCIES. BIOCHIMICA ET BIOPHYSICA ACTA, 856 (3): 457-470 APR 25 1986
• WANG, CT; SHIAO, YJ; CHEN, JC; et al. ESTIMATION OF THE PHOSPHOLIPID DISTRIBUTION IN THE HUMAN-PLATELET PLASMA-MEMBRANE BASED ON THE EFFECT OF PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS. BIOCHIMICA ET BIOPHYSICA ACTA, 856 (2): 244-258 APR 14 1986
• ROSENBERG, P; CONDREA, E; RAPUANO, BE; et al. DISSOCIATION OF PHARMACOLOGICAL AND ENZYMATIC-ACTIVITIES OF SNAKE-VENOM PHOSPHOLIPASES-A2 BY MODIFICATION OF CARBOXYLATE GROUPS. BIOCHEMICAL PHARMACOLOGY, 32 (23): 3525-3530 1983
• ZAN, YP; CONDREA, E; YANG, CC; et al. PHOSPHOLIPID HYDROLYSIS IN SERUM-LIPOPROTEINS BY A BASIC PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS SNAKE-VENOM AND AN ACIDIC PHOSPHOLIPASE-A2 FROM NAJA-NAJA ATRA SNAKE-VENOM. TOXICON, 21 (4): 481-490 1983
• WANG, CT; CHANG, SM; TSAI, W; et al. LIPID DOMAINS IN HUMAN-PLATELET PLASMA-MEMBRANE. THROMBOSIS AND HAEMOSTASIS, 50 (1): 338-338 1983
• CONDREA, E; YANG, CC; ROSENBERG, P. ANTICOAGULANT ACTIVITY AND PLASMA PHOSPHATIDYLSERINE HYDROLYSIS BY SNAKE-VENOM PHOSPHOLIPASES-A2. THROMBOSIS AND HAEMOSTASIS, 49 (2): 151-151 1983
• CONDREA, E; RAPUANO, BE; FLETCHER, JE; et al. ETHOXYFORMYLATION AND GUANIDINATION OF SNAKE-VENOM PHOSPHOLIPASES-A2 - EFFECTS ON ENZYMATIC-ACTIVITY, LETHALITY AND SOME PHARMACOLOGICAL PROPERTIES. TOXICON, 21 (2): 209-218 1983
• ROSENBERG, P; RAPUANO, BE; SOONS, KR; et al. MODIFICATION OF CARBOXYLATE GROUPS IN PHOSPHOLIPASE-A2 FROM SNAKE-VENOMS SUGGESTS THE PRESENCE OF SEPARATE PHARMACOLOGICAL AND ENZYMATIC SITES. FEDERATION PROCEEDINGS, 42 (4): 877-877 1983
• RAPUANO, BE; YANG, CC; ROSENBERG, P. LETHAL POTENCIES OF CENTRALLY ADMINISTERED PHOSPHOLIPASES-A2 IN RELATIONSHIP TO BINDING TO AND PHOSPHOLIPID HYDROLYSIS OF SYNAPTIC PLASMA-MEMBRANES. FEDERATION PROCEEDINGS, 42 (4): 877-877 1983
• CONDREA, E; RAPUANO, BE; SOONS, KR; et al. EFFECT OF METHYLATION OF HISTIDINE-48 ON SOME ENZYMATIC AND PHARMACOLOGICAL ACTIVITIES OF SNAKE-VENOM PHOSPHOLIPASES A2. LIFE SCIENCES, 32 (13): 1455-1461 1983
• FLETCHER, JE; YANG, CC; ROSENBERG, P. BASIC PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS SNAKE-VENOM - PHOSPHOLIPID HYDROLYSIS AND EFFECTS ON ELECTRICAL AND CONTRACTILE ACTIVITY OF THE RAT-HEART. TOXICOLOGY AND APPLIED PHARMACOLOGY, 66 (1): 39-54 1982
• YANG, CC; KING, K; SUN, TP. CARBAMYLATION WITH CYANATE OF BASIC PHOSPHOLIPASE-A2 FROM THE VENOM OF NAJA-NIGRICOLLIS (SPITTING COBRA). TOXICON, 19 (6): 783-795 1981
• GALAT, A; DEGELAEN, JP; YANG, CC; et al. REVERSED UNFOLDING-REFOLDING PROCESS OF COBRA NEUROTOXIN. BIOCHEMISTRY, 20 (26): 7415-7423 1981
• YANG, CC; KING, K. CHEMICAL MODIFICATION OF THE HISTIDINE RESIDUE IN PHOSPHOLIPASE-A2 FROM THE HEMACHATUS-HAEMACHATUS SNAKE-VENOM. TOXICON, 18 (5-6): 529-& 1980
• YANG, CC; KING, K. CHEMICAL MODIFICATION OF THE HISTIDINE RESIDUE IN BASIC PHOSPHOLIPASE-A2 FROM THE VENOM OF NAJA-NIGRICOLLIS. BIOCHIMICA ET BIOPHYSICA ACTA, 614 (2): 373-388 1980